| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Knicks | 97 | Lakers | 101 |
| November | 4, 2010 | Lakers | 101 | Raptors | 90 |
| November | 5, 2010 | Lakers | 111 | 76ers | 80 |
| November | 7, 2010 | Lakers | 85 | Magic | 86 |
| November | 9, 2010 | Lakers | 87 | Pacers | 97 |
| November | 11, 2010 | Bulls | 87 | Lakers | 100 |
| November | 13, 2010 | Mavericks | 103 | Lakers | 94 |
| November | 14, 2010 | Wizards | 87 | Lakers | 85 |
| November | 16, 2010 | Hornets | 79 | Lakers | 86 |
| November | 17, 2010 | Blazers | 91 | Lakers | 106 |
| November | 18, 2010 | Lakers | 120 | Heat | 109 |
| November | 22, 2010 | Lakers | 109 | Nets | 101 |
| November | 27, 2010 | Bulls | 82 | Lakers | 93 |
| November | 29, 2010 | Mavericks | 93 | Lakers | 90 |
| November | 30, 2010 | Lakers | 92 | Hornets | 74 |
| December | 2, 2010 | Lakers | 98 | Bucks | 99 |
| December | 4, 2010 | Lakers | 93 | Pacers | 92 |
| December | 5, 2010 | Lakers | 75 | Timberwolves | 88 |
| December | 7, 2010 | Lakers | 88 | Celtics | 110 |
| December | 12, 2010 | Mavericks | 71 | Lakers | 91 |
| December | 13, 2010 | Lakers | 85 | Timberwolves | 73 |
| December | 14, 2010 | Lakers | 95 | Nuggets | 86 |
| December | 16, 2010 | Lakers | 74 | Blazers | 69 |
| December | 17, 2010 | Kings | 75 | Lakers | 113 |
| December | 18, 2010 | Nuggets | 103 | Lakers | 78 |
| December | 20, 2010 | Thunder | 78 | Lakers | 100 |
| December | 22, 2010 | Grizzlies | | Lakers | |
| December | 25, 2010 | Jazz | | Lakers | |
| December | 26, 2010 | Cavaliers | | Lakers | |
| December | 27, 2010 | Suns | | Lakers | |
| December | 28, 2010 | Bulls | | Lakers | |
| January | 6, 2011 | Lakers | | SuperSonics | |
| January | 10, 2011 | Hornets | | Lakers | |
| January | 16, 2011 | Hornets | | Lakers | |
| January | 17, 2011 | Celtics | | Lakers | |
| January | 18, 2011 | Lakers | | Jazz | |
| January | 20, 2011 | Blazers | | Lakers | |
| January | 23, 2011 | Jazz | | Lakers | |
| January | 24, 2011 | Lakers | | Mavericks | |
| January | 26, 2011 | Lakers | | Kings | |
| January | 28, 2011 | SuperSonics | | Lakers | |
| January | 31, 2011 | Pistons | | Lakers | |
| February | 2, 2011 | Kings | | Lakers | |
| February | 4, 2011 | Lakers | | Hornets | |
| February | 7, 2011 | Blazers | | Lakers | |
| February | 12, 2011 | Lakers | | Pistons | |
| February | 13, 2011 | Lakers | | Bulls | |
| February | 16, 2011 | 76ers | | Lakers | |
| February | 18, 2011 | Kings | | Lakers | |
| February | 24, 2011 | Magic | | Lakers | |
| February | 28, 2011 | Raptors | | Lakers | |
| March | 1, 2011 | Raptors | | Lakers | |
| March | 3, 2011 | Lakers | | Wizards | |
| March | 4, 2011 | Lakers | | Suns | |
| March | 5, 2011 | Lakers | | Cavaliers | |
| March | 8, 2011 | Lakers | | Kings | |
| March | 14, 2011 | Nets | | Lakers | |
| March | 15, 2011 | Nets | | Lakers | |
| March | 19, 2011 | Lakers | | Knicks | |
| March | 22, 2011 | Lakers | | Raptors | |
| March | 25, 2011 | Lakers | | Jazz | |
| March | 26, 2011 | Lakers | | Blazers | |
| March | 28, 2011 | Lakers | | SuperSonics | |
| March | 31, 2011 | Lakers | | Nets | |
| April | 3, 2011 | Lakers | | Knicks | |
| April | 5, 2011 | Raptors | | Lakers | |
| April | 6, 2011 | Bucks | | Lakers | |
| April | 8, 2011 | Heat | | Lakers | |
| April | 11, 2011 | Pacers | | Lakers | |
| April | 13, 2011 | Lakers | | Bulls | |
| April | 15, 2011 | Timberwolves | | Lakers | |
| April | 17, 2011 | Lakers | | Pacers | |
| April | 18, 2011 | Lakers | | Thunder | |
| April | 22, 2011 | Lakers | | Nets | |
| April | 24, 2011 | Lakers | | Grizzlies | |
| April | 26, 2011 | Lakers | | Timberwolves | |
| April | 27, 2011 | Pacers | | Lakers | |
| April | 29, 2011 | Lakers | | Blazers | |
| April | 30, 2011 | Pelicans | | Lakers | |
| May | 1, 2011 | Lakers | | Pelicans | |
| May | 2, 2011 | Lakers | | Timberwolves | |
| May | 3, 2011 | Timberwolves | | Lakers | |