| month | day | visitor | score | home | score |
|---|
| November | 2, 2012 | Pistons | 92 | Celtics | 110 |
| November | 4, 2012 | Pistons | 69 | Hornets | 75 |
| November | 6, 2012 | Heat | 117 | Pistons | 105 |
| November | 12, 2012 | Lakers | 84 | Pistons | 80 |
| November | 14, 2012 | Pistons | 70 | Mavericks | 99 |
| November | 15, 2012 | Pistons | 98 | Knicks | 113 |
| November | 19, 2012 | Pistons | 110 | Grizzlies | 105 |
| November | 23, 2012 | Pistons | 106 | Magic | 89 |
| November | 28, 2012 | Wizards | 103 | Pistons | 110 |
| November | 29, 2012 | Blazers | 89 | Pistons | 120 |
| November | 30, 2012 | 76ers | 113 | Pistons | 100 |
| December | 2, 2012 | Pistons | 100 | Bucks | 105 |
| December | 3, 2012 | Cavaliers | 92 | Pistons | 102 |
| December | 5, 2012 | Bucks | 120 | Pistons | 97 |
| December | 6, 2012 | Heat | 113 | Pistons | 138 |
| December | 10, 2012 | Pistons | 91 | Raptors | 121 |
| December | 11, 2012 | Pistons | 104 | Thunder | 122 |
| December | 14, 2012 | Heat | 118 | Pistons | 115 |
| December | 15, 2012 | Magic | 102 | Pistons | 105 |
| December | 16, 2012 | Pistons | 77 | Bulls | 134 |
| December | 24, 2012 | Pistons | 107 | Grizzlies | 104 |
| December | 26, 2012 | Pistons | 100 | Suns | 111 |
| December | 28, 2012 | Pistons | 101 | Thunder | 123 |
| December | 30, 2012 | Pistons | 100 | Bucks | 104 |
| December | 31, 2012 | Pistons | 103 | Pacers | 94 |
| January | 3, 2013 | Cavaliers | 95 | Pistons | 108 |
| January | 4, 2013 | 76ers | 99 | Pistons | 108 |
| January | 6, 2013 | Thunder | 113 | Pistons | 101 |
| January | 7, 2013 | Pelicans | 97 | Pistons | 79 |
| January | 8, 2013 | Pistons | 112 | Suns | 108 |
| January | 11, 2013 | Pistons | 115 | Lakers | 106 |
| January | 15, 2013 | Pistons | | Heat | |
| January | 16, 2013 | Nuggets | | Pistons | |
| January | 17, 2013 | Pistons | | 76ers | |
| January | 19, 2013 | Suns | | Pistons | |
| January | 21, 2013 | Pistons | | Thunder | |
| January | 22, 2013 | Pistons | | Wizards | |
| January | 23, 2013 | Thunder | | Pistons | |
| January | 24, 2013 | Wizards | | Pistons | |
| January | 25, 2013 | Cavaliers | | Pistons | |
| January | 27, 2013 | Grizzlies | | Pistons | |
| January | 29, 2013 | Knicks | | Pistons | |
| January | 31, 2013 | Pistons | | 76ers | |
| February | 1, 2013 | Pistons | | Cavaliers | |
| February | 4, 2013 | Kings | | Pistons | |
| February | 5, 2013 | Hornets | | Pistons | |
| February | 15, 2013 | Pistons | | Jazz | |
| February | 16, 2013 | Suns | | Pistons | |
| February | 18, 2013 | Pelicans | | Pistons | |
| February | 21, 2013 | Pistons | | Nets | |
| February | 23, 2013 | Bucks | | Pistons | |
| February | 26, 2013 | Pistons | | Magic | |
| February | 28, 2013 | Celtics | | Pistons | |
| March | 5, 2013 | Pacers | | Pistons | |
| March | 6, 2013 | Pistons | | Timberwolves | |
| March | 13, 2013 | Pistons | | Blazers | |
| March | 14, 2013 | Pistons | | SuperSonics | |
| March | 15, 2013 | Pistons | | Kings | |
| March | 16, 2013 | Mavericks | | Pistons | |
| March | 17, 2013 | Pistons | | 76ers | |
| March | 18, 2013 | Pistons | | Suns | |
| March | 25, 2013 | Jazz | | Pistons | |
| March | 26, 2013 | Pistons | | Magic | |
| March | 29, 2013 | Nuggets | | Pistons | |
| March | 31, 2013 | Pistons | | Bucks | |
| April | 1, 2013 | Pistons | | Cavaliers | |
| April | 3, 2013 | Celtics | | Pistons | |
| April | 7, 2013 | Magic | | Pistons | |
| April | 8, 2013 | Pistons | | Celtics | |
| April | 11, 2013 | Pelicans | | Pistons | |
| April | 13, 2013 | Pistons | | Grizzlies | |
| April | 14, 2013 | SuperSonics | | Pistons | |
| April | 15, 2013 | Pistons | | Celtics | |
| April | 17, 2013 | Raptors | | Pistons | |
| April | 19, 2013 | Pistons | | Pelicans | |
| April | 20, 2013 | Timberwolves | | Pistons | |
| April | 22, 2013 | Wizards | | Pistons | |
| April | 24, 2013 | Bulls | | Pistons | |
| April | 27, 2013 | Pistons | | Nuggets | |
| April | 28, 2013 | Nuggets | | Pistons | |
| April | 29, 2013 | Nets | | Pistons | |
| May | 3, 2013 | Pistons | | Nuggets | |