| month | day | visitor | score | home | score |
|---|
| November | 2, 2011 | Magic | 87 | Pistons | 82 |
| November | 3, 2011 | Pistons | 86 | Bulls | 102 |
| November | 4, 2011 | 76ers | 109 | Pistons | 88 |
| November | 5, 2011 | Pelicans | 92 | Pistons | 120 |
| November | 6, 2011 | Pistons | 99 | Grizzlies | 111 |
| November | 7, 2011 | Heat | 112 | Pistons | 108 |
| November | 11, 2011 | Pistons | 96 | Nets | 100 |
| November | 12, 2011 | Thunder | 106 | Pistons | 99 |
| November | 13, 2011 | Pelicans | 110 | Pistons | 130 |
| November | 15, 2011 | SuperSonics | 124 | Pistons | 120 |
| November | 16, 2011 | Wizards | 113 | Pistons | 100 |
| November | 17, 2011 | Knicks | 125 | Pistons | 122 |
| November | 18, 2011 | Cavaliers | 115 | Pistons | 113 |
| November | 19, 2011 | Pistons | 110 | Cavaliers | 102 |
| November | 20, 2011 | Kings | 119 | Pistons | 123 |
| November | 22, 2011 | Pelicans | 111 | Pistons | 97 |
| November | 26, 2011 | Pistons | | Celtics | |
| November | 28, 2011 | Grizzlies | | Pistons | |
| November | 29, 2011 | Pistons | | Bucks | |
| December | 1, 2011 | Thunder | | Pistons | |
| December | 2, 2011 | Pistons | | Suns | |
| December | 4, 2011 | Pistons | | Bucks | |
| December | 6, 2011 | Mavericks | | Pistons | |
| December | 8, 2011 | Celtics | | Pistons | |
| December | 13, 2011 | Pistons | | Thunder | |
| December | 14, 2011 | Pistons | | Blazers | |
| December | 15, 2011 | Bulls | | Pistons | |
| December | 16, 2011 | Pistons | | Cavaliers | |
| December | 17, 2011 | Bucks | | Pistons | |
| December | 23, 2011 | Pistons | | Knicks | |
| December | 29, 2011 | Pistons | | 76ers | |
| December | 31, 2011 | 76ers | | Pistons | |
| January | 1, 2012 | Lakers | | Pistons | |
| January | 3, 2012 | Pistons | | Suns | |
| January | 5, 2012 | Cavaliers | | Pistons | |
| January | 9, 2012 | Suns | | Pistons | |
| January | 10, 2012 | Pistons | | Jazz | |
| January | 12, 2012 | Pistons | | Hornets | |
| January | 13, 2012 | Pistons | | Magic | |
| January | 20, 2012 | Pistons | | Grizzlies | |
| January | 21, 2012 | Nuggets | | Pistons | |
| January | 24, 2012 | Pistons | | Nuggets | |
| January | 31, 2012 | Pistons | | Timberwolves | |
| February | 1, 2012 | Raptors | | Pistons | |
| February | 6, 2012 | Timberwolves | | Pistons | |
| February | 17, 2012 | Nets | | Pistons | |
| February | 22, 2012 | Nuggets | | Pistons | |
| February | 26, 2012 | Pistons | | Thunder | |
| February | 27, 2012 | Pistons | | Mavericks | |
| February | 28, 2012 | Pistons | | 76ers | |
| March | 3, 2012 | Pistons | | Nuggets | |
| March | 8, 2012 | Magic | | Pistons | |
| March | 9, 2012 | Pistons | | Raptors | |
| March | 11, 2012 | Suns | | Pistons | |
| March | 12, 2012 | Jazz | | Pistons | |
| March | 13, 2012 | Pistons | | Suns | |
| March | 16, 2012 | Pistons | | Pacers | |
| March | 17, 2012 | Cavaliers | | Pistons | |
| March | 19, 2012 | Pistons | | 76ers | |
| March | 20, 2012 | Wizards | | Pistons | |
| March | 22, 2012 | Pistons | | Pelicans | |
| March | 27, 2012 | Pistons | | Bucks | |
| March | 28, 2012 | Pistons | | Kings | |
| March | 29, 2012 | Pistons | | Magic | |
| April | 3, 2012 | Nuggets | | Pistons | |
| April | 5, 2012 | Pistons | | Grizzlies | |
| April | 7, 2012 | Pistons | | SuperSonics | |
| April | 8, 2012 | Pistons | | Celtics | |
| April | 9, 2012 | Pistons | | Wizards | |
| April | 11, 2012 | Wizards | | Pistons | |
| April | 13, 2012 | Pistons | | Thunder | |
| April | 17, 2012 | Blazers | | Pistons | |
| April | 18, 2012 | Pistons | | Lakers | |
| April | 19, 2012 | Bucks | | Pistons | |
| April | 21, 2012 | Heat | | Pistons | |
| April | 22, 2012 | Hornets | | Pistons | |
| April | 23, 2012 | Pistons | | Celtics | |
| April | 25, 2012 | Pacers | | Pistons | |
| April | 26, 2012 | Pistons | | Magic | |
| April | 29, 2012 | Pistons | | Heat | |
| April | 30, 2012 | Heat | | Pistons | |
| May | 3, 2012 | Celtics | | Pistons | |