| month | day | visitor | score | home | score |
|---|
| November | 3, 2010 | Pistons | 114 | Celtics | 118 |
| November | 4, 2010 | Pistons | 84 | Grizzlies | 96 |
| November | 5, 2010 | Pistons | 105 | Kings | 108 |
| November | 6, 2010 | 76ers | 93 | Pistons | 117 |
| November | 7, 2010 | Nets | 115 | Pistons | 108 |
| November | 12, 2010 | Pistons | 87 | Mavericks | 116 |
| November | 18, 2010 | Pistons | 72 | Timberwolves | 93 |
| November | 19, 2010 | Pistons | 83 | Magic | 103 |
| November | 20, 2010 | Mavericks | 112 | Pistons | 107 |
| November | 25, 2010 | Celtics | 105 | Pistons | 97 |
| November | 26, 2010 | Pistons | 80 | Suns | 115 |
| November | 27, 2010 | Pistons | 106 | SuperSonics | 132 |
| November | 28, 2010 | Pistons | 82 | Suns | 103 |
| November | 30, 2010 | Pistons | 91 | Grizzlies | 78 |
| December | 5, 2010 | Grizzlies | 85 | Pistons | 97 |
| December | 6, 2010 | Wizards | 109 | Pistons | 114 |
| December | 7, 2010 | Cavaliers | 82 | Pistons | 93 |
| December | 8, 2010 | Pistons | 83 | Magic | 100 |
| December | 9, 2010 | Pistons | 97 | Bucks | 133 |
| December | 11, 2010 | 76ers | 111 | Pistons | 105 |
| December | 12, 2010 | Raptors | 129 | Pistons | 106 |
| December | 15, 2010 | Hornets | 80 | Pistons | 99 |
| December | 18, 2010 | Pistons | 97 | Celtics | 129 |
| December | 19, 2010 | Pistons | 55 | Blazers | 100 |
| December | 23, 2010 | Pistons | | Heat | |
| December | 25, 2010 | Bucks | | Pistons | |
| December | 28, 2010 | Pistons | | Cavaliers | |
| December | 29, 2010 | Heat | | Pistons | |
| December | 31, 2010 | Pistons | | 76ers | |
| January | 1, 2011 | Pistons | | Magic | |
| January | 3, 2011 | Thunder | | Pistons | |
| January | 9, 2011 | Pistons | | Hornets | |
| January | 13, 2011 | Thunder | | Pistons | |
| January | 14, 2011 | Pistons | | Knicks | |
| January | 15, 2011 | Pistons | | Suns | |
| January | 17, 2011 | Pistons | | Bucks | |
| January | 22, 2011 | SuperSonics | | Pistons | |
| January | 25, 2011 | Jazz | | Pistons | |
| January | 28, 2011 | Pistons | | Grizzlies | |
| January | 29, 2011 | Pistons | | 76ers | |
| January | 31, 2011 | Pistons | | Lakers | |
| February | 1, 2011 | Cavaliers | | Pistons | |
| February | 2, 2011 | Pistons | | Thunder | |
| February | 5, 2011 | Pelicans | | Pistons | |
| February | 6, 2011 | Blazers | | Pistons | |
| February | 8, 2011 | Pistons | | 76ers | |
| February | 12, 2011 | Lakers | | Pistons | |
| February | 16, 2011 | Cavaliers | | Pistons | |
| February | 21, 2011 | Timberwolves | | Pistons | |
| February | 22, 2011 | Suns | | Pistons | |
| February | 23, 2011 | Pelicans | | Pistons | |
| February | 27, 2011 | Wizards | | Pistons | |
| March | 1, 2011 | Magic | | Pistons | |
| March | 2, 2011 | Heat | | Pistons | |
| March | 3, 2011 | Celtics | | Pistons | |
| March | 5, 2011 | Pistons | | Nuggets | |
| March | 11, 2011 | Heat | | Pistons | |
| March | 12, 2011 | Pacers | | Pistons | |
| March | 15, 2011 | Pelicans | | Pistons | |
| March | 17, 2011 | Magic | | Pistons | |
| March | 18, 2011 | Pistons | | Bulls | |
| March | 20, 2011 | Bucks | | Pistons | |
| March | 27, 2011 | Wizards | | Pistons | |
| March | 28, 2011 | Pistons | | Pacers | |
| March | 29, 2011 | Pistons | | Nets | |
| March | 31, 2011 | Pistons | | Raptors | |
| April | 1, 2011 | Pistons | | Cavaliers | |
| April | 2, 2011 | Pistons | | Bucks | |
| April | 6, 2011 | Pistons | | Jazz | |
| April | 9, 2011 | Pistons | | Wizards | |
| April | 10, 2011 | Nuggets | | Pistons | |
| April | 12, 2011 | Knicks | | Pistons | |
| April | 13, 2011 | Pistons | | Thunder | |
| April | 14, 2011 | Nuggets | | Pistons | |
| April | 18, 2011 | Pistons | | Nuggets | |
| April | 20, 2011 | Kings | | Pistons | |
| April | 21, 2011 | Nuggets | | Pistons | |
| April | 22, 2011 | Bulls | | Pistons | |
| April | 24, 2011 | Pistons | | Celtics | |
| April | 27, 2011 | Pistons | | Pelicans | |
| April | 28, 2011 | Suns | | Pistons | |
| April | 30, 2011 | Pistons | | Thunder | |