| month | day | visitor | score | home | score |
|---|
| November | 4, 2011 | Cavaliers | 112 | Pelicans | 137 |
| November | 6, 2011 | Cavaliers | 96 | Wizards | 109 |
| November | 8, 2011 | Cavaliers | 113 | Wizards | 122 |
| November | 10, 2011 | Cavaliers | 97 | Grizzlies | 106 |
| November | 13, 2011 | Bucks | 115 | Cavaliers | 119 |
| November | 14, 2011 | Cavaliers | 100 | Grizzlies | 121 |
| November | 18, 2011 | Cavaliers | 115 | Pistons | 113 |
| November | 19, 2011 | Pistons | 110 | Cavaliers | 102 |
| November | 21, 2011 | Timberwolves | 103 | Cavaliers | 85 |
| November | 22, 2011 | Suns | 117 | Cavaliers | 102 |
| November | 29, 2011 | Cavaliers | | Lakers | |
| December | 2, 2011 | Cavaliers | | Pelicans | |
| December | 4, 2011 | Thunder | | Cavaliers | |
| December | 8, 2011 | Suns | | Cavaliers | |
| December | 12, 2011 | Knicks | | Cavaliers | |
| December | 16, 2011 | Pistons | | Cavaliers | |
| December | 18, 2011 | Jazz | | Cavaliers | |
| December | 20, 2011 | Lakers | | Cavaliers | |
| December | 22, 2011 | Mavericks | | Cavaliers | |
| December | 23, 2011 | Cavaliers | | Bucks | |
| December | 27, 2011 | Cavaliers | | Pelicans | |
| December | 28, 2011 | Bucks | | Cavaliers | |
| January | 1, 2012 | Cavaliers | | Hornets | |
| January | 3, 2012 | 76ers | | Cavaliers | |
| January | 4, 2012 | Cavaliers | | Thunder | |
| January | 5, 2012 | Cavaliers | | Pistons | |
| January | 8, 2012 | Celtics | | Cavaliers | |
| January | 10, 2012 | Cavaliers | | Heat | |
| January | 12, 2012 | Celtics | | Cavaliers | |
| January | 13, 2012 | Cavaliers | | Bulls | |
| January | 14, 2012 | Magic | | Cavaliers | |
| January | 15, 2012 | Cavaliers | | 76ers | |
| January | 16, 2012 | Cavaliers | | Raptors | |
| January | 18, 2012 | 76ers | | Cavaliers | |
| January | 19, 2012 | Thunder | | Cavaliers | |
| January | 20, 2012 | Nuggets | | Cavaliers | |
| January | 22, 2012 | Celtics | | Cavaliers | |
| January | 23, 2012 | Grizzlies | | Cavaliers | |
| January | 26, 2012 | Cavaliers | | Knicks | |
| January | 27, 2012 | Cavaliers | | Suns | |
| January | 29, 2012 | Nets | | Cavaliers | |
| January | 31, 2012 | Thunder | | Cavaliers | |
| February | 5, 2012 | Cavaliers | | 76ers | |
| February | 6, 2012 | Bulls | | Cavaliers | |
| February | 7, 2012 | SuperSonics | | Cavaliers | |
| February | 12, 2012 | Cavaliers | | Blazers | |
| February | 13, 2012 | Cavaliers | | Nuggets | |
| February | 15, 2012 | Cavaliers | | Celtics | |
| February | 19, 2012 | 76ers | | Cavaliers | |
| February | 20, 2012 | Blazers | | Cavaliers | |
| February | 23, 2012 | Grizzlies | | Cavaliers | |
| February | 24, 2012 | Raptors | | Cavaliers | |
| February | 28, 2012 | Cavaliers | | Bucks | |
| March | 1, 2012 | Cavaliers | | Kings | |
| March | 2, 2012 | Cavaliers | | Timberwolves | |
| March | 11, 2012 | Cavaliers | | Heat | |
| March | 14, 2012 | Cavaliers | | Magic | |
| March | 17, 2012 | Cavaliers | | Pistons | |
| March | 18, 2012 | Magic | | Cavaliers | |
| March | 22, 2012 | Hornets | | Cavaliers | |
| March | 25, 2012 | Cavaliers | | Thunder | |
| March | 26, 2012 | Wizards | | Cavaliers | |
| March | 27, 2012 | Kings | | Cavaliers | |
| March | 30, 2012 | Bucks | | Cavaliers | |
| March | 31, 2012 | Cavaliers | | Wizards | |
| April | 2, 2012 | Cavaliers | | Magic | |
| April | 6, 2012 | Grizzlies | | Cavaliers | |
| April | 8, 2012 | Heat | | Cavaliers | |
| April | 9, 2012 | Cavaliers | | Mavericks | |
| April | 11, 2012 | Pelicans | | Cavaliers | |
| April | 14, 2012 | Suns | | Cavaliers | |
| April | 15, 2012 | Bucks | | Cavaliers | |
| April | 17, 2012 | Cavaliers | | Pacers | |
| April | 18, 2012 | Cavaliers | | Suns | |
| April | 19, 2012 | Cavaliers | | Heat | |
| April | 20, 2012 | Cavaliers | | Nets | |
| April | 21, 2012 | Cavaliers | | Nuggets | |
| April | 22, 2012 | Cavaliers | | Nuggets | |
| April | 23, 2012 | Cavaliers | | Jazz | |
| April | 29, 2012 | Pacers | | Cavaliers | |
| April | 30, 2012 | Magic | | Cavaliers | |
| May | 1, 2012 | Cavaliers | | SuperSonics | |