| month | day | visitor | score | home | score |
|---|
| November | 2, 2012 | Cavaliers | 90 | Pacers | 104 |
| November | 3, 2012 | Cavaliers | 74 | Mavericks | 100 |
| November | 5, 2012 | Hornets | 62 | Cavaliers | 61 |
| November | 7, 2012 | Thunder | 99 | Cavaliers | 81 |
| November | 8, 2012 | SuperSonics | 117 | Cavaliers | 89 |
| November | 9, 2012 | Suns | 125 | Cavaliers | 104 |
| November | 10, 2012 | Celtics | 101 | Cavaliers | 73 |
| November | 14, 2012 | Pacers | 101 | Cavaliers | 105 |
| November | 16, 2012 | Cavaliers | 76 | Magic | 92 |
| November | 19, 2012 | Heat | 93 | Cavaliers | 84 |
| November | 20, 2012 | Cavaliers | 89 | Jazz | 93 |
| November | 22, 2012 | Cavaliers | 73 | Pelicans | 77 |
| November | 25, 2012 | Timberwolves | 71 | Cavaliers | 85 |
| November | 26, 2012 | Magic | 74 | Cavaliers | 88 |
| November | 28, 2012 | Cavaliers | 120 | Grizzlies | 139 |
| December | 3, 2012 | Cavaliers | 92 | Pistons | 102 |
| December | 4, 2012 | Cavaliers | 98 | Heat | 96 |
| December | 5, 2012 | Suns | 97 | Cavaliers | 91 |
| December | 6, 2012 | Cavaliers | 75 | Nuggets | 81 |
| December | 7, 2012 | Cavaliers | 75 | Bucks | 121 |
| December | 9, 2012 | Cavaliers | 97 | SuperSonics | 121 |
| December | 10, 2012 | 76ers | 90 | Cavaliers | 85 |
| December | 13, 2012 | Cavaliers | 83 | Thunder | 102 |
| December | 15, 2012 | Cavaliers | 65 | Kings | 102 |
| December | 20, 2012 | Lakers | 77 | Cavaliers | 63 |
| December | 21, 2012 | Bucks | 91 | Cavaliers | 79 |
| December | 24, 2012 | Cavaliers | 72 | Wizards | 94 |
| December | 25, 2012 | Magic | 87 | Cavaliers | 79 |
| December | 26, 2012 | Blazers | 100 | Cavaliers | 92 |
| December | 28, 2012 | Cavaliers | 93 | Suns | 122 |
| December | 29, 2012 | Grizzlies | 107 | Cavaliers | 105 |
| January | 1, 2013 | Cavaliers | 82 | Timberwolves | 93 |
| January | 3, 2013 | Cavaliers | 95 | Pistons | 108 |
| January | 5, 2013 | Cavaliers | 91 | Heat | 113 |
| January | 7, 2013 | Cavaliers | 77 | Wizards | 80 |
| January | 9, 2013 | Suns | 117 | Cavaliers | 99 |
| January | 12, 2013 | Cavaliers | 90 | Lakers | 88 |
| January | 14, 2013 | Bucks | 82 | Cavaliers | 85 |
| January | 18, 2013 | Nets | | Cavaliers | |
| January | 23, 2013 | Bucks | | Cavaliers | |
| January | 24, 2013 | Magic | | Cavaliers | |
| January | 25, 2013 | Cavaliers | | Pistons | |
| January | 27, 2013 | Cavaliers | | Nuggets | |
| January | 28, 2013 | 76ers | | Cavaliers | |
| January | 31, 2013 | Mavericks | | Cavaliers | |
| February | 1, 2013 | Pistons | | Cavaliers | |
| February | 7, 2013 | Celtics | | Cavaliers | |
| February | 8, 2013 | Kings | | Cavaliers | |
| February | 13, 2013 | Thunder | | Cavaliers | |
| February | 17, 2013 | Cavaliers | | Pelicans | |
| February | 18, 2013 | Knicks | | Cavaliers | |
| February | 19, 2013 | Wizards | | Cavaliers | |
| February | 28, 2013 | Cavaliers | | Magic | |
| March | 1, 2013 | Cavaliers | | Wizards | |
| March | 8, 2013 | 76ers | | Cavaliers | |
| March | 12, 2013 | Cavaliers | | Hornets | |
| March | 13, 2013 | Thunder | | Cavaliers | |
| March | 14, 2013 | Cavaliers | | Nets | |
| March | 16, 2013 | Bucks | | Cavaliers | |
| March | 18, 2013 | Nuggets | | Cavaliers | |
| March | 20, 2013 | Pelicans | | Cavaliers | |
| March | 21, 2013 | Cavaliers | | Bulls | |
| March | 24, 2013 | Cavaliers | | Raptors | |
| March | 25, 2013 | Celtics | | Cavaliers | |
| March | 27, 2013 | Raptors | | Cavaliers | |
| March | 28, 2013 | Cavaliers | | Suns | |
| March | 29, 2013 | Cavaliers | | Celtics | |
| March | 31, 2013 | Grizzlies | | Cavaliers | |
| April | 1, 2013 | Pistons | | Cavaliers | |
| April | 3, 2013 | Cavaliers | | Pelicans | |
| April | 10, 2013 | Bulls | | Cavaliers | |
| April | 11, 2013 | Cavaliers | | Grizzlies | |
| April | 12, 2013 | Jazz | | Cavaliers | |
| April | 15, 2013 | Cavaliers | | Bucks | |
| April | 17, 2013 | Cavaliers | | Blazers | |
| April | 19, 2013 | Cavaliers | | 76ers | |
| April | 20, 2013 | Cavaliers | | 76ers | |
| April | 23, 2013 | Cavaliers | | Thunder | |
| April | 25, 2013 | Cavaliers | | Knicks | |
| April | 26, 2013 | Cavaliers | | Nuggets | |
| April | 27, 2013 | Cavaliers | | Heat | |
| May | 2, 2013 | Grizzlies | | Cavaliers | |