| month | day | visitor | score | home | score |
|---|
| November | 3, 2010 | Cavaliers | 78 | Thunder | 75 |
| November | 7, 2010 | Suns | 102 | Cavaliers | 104 |
| November | 9, 2010 | Cavaliers | 92 | Magic | 88 |
| November | 13, 2010 | Cavaliers | 96 | Pelicans | 105 |
| November | 19, 2010 | Cavaliers | 86 | Heat | 113 |
| November | 20, 2010 | Cavaliers | 80 | Grizzlies | 87 |
| November | 21, 2010 | Cavaliers | 95 | Heat | 109 |
| November | 23, 2010 | Thunder | 83 | Cavaliers | 95 |
| November | 24, 2010 | Magic | 93 | Cavaliers | 96 |
| November | 26, 2010 | 76ers | 77 | Cavaliers | 81 |
| November | 29, 2010 | Cavaliers | 90 | Bucks | 95 |
| November | 30, 2010 | Kings | 76 | Cavaliers | 72 |
| December | 2, 2010 | Celtics | 106 | Cavaliers | 95 |
| December | 3, 2010 | Cavaliers | 89 | Nuggets | 80 |
| December | 6, 2010 | Cavaliers | 79 | Nuggets | 111 |
| December | 7, 2010 | Cavaliers | 82 | Pistons | 93 |
| December | 10, 2010 | Magic | 105 | Cavaliers | 68 |
| December | 14, 2010 | Pacers | 76 | Cavaliers | 90 |
| December | 15, 2010 | Cavaliers | 79 | 76ers | 78 |
| December | 16, 2010 | Bucks | 96 | Cavaliers | 86 |
| December | 17, 2010 | Cavaliers | 80 | Nuggets | 107 |
| December | 18, 2010 | Cavaliers | 83 | Wizards | 86 |
| December | 19, 2010 | Bucks | 79 | Cavaliers | 90 |
| December | 20, 2010 | Cavaliers | 100 | SuperSonics | 110 |
| December | 23, 2010 | Thunder | | Cavaliers | |
| December | 24, 2010 | Cavaliers | | Knicks | |
| December | 26, 2010 | Cavaliers | | Lakers | |
| December | 27, 2010 | Cavaliers | | Pelicans | |
| December | 28, 2010 | Pistons | | Cavaliers | |
| December | 30, 2010 | Grizzlies | | Cavaliers | |
| January | 1, 2011 | Cavaliers | | Grizzlies | |
| January | 2, 2011 | Celtics | | Cavaliers | |
| January | 3, 2011 | Blazers | | Cavaliers | |
| January | 4, 2011 | Cavaliers | | Blazers | |
| January | 6, 2011 | Nuggets | | Cavaliers | |
| January | 8, 2011 | Nets | | Cavaliers | |
| January | 9, 2011 | Grizzlies | | Cavaliers | |
| January | 15, 2011 | Heat | | Cavaliers | |
| January | 16, 2011 | Cavaliers | | Nets | |
| January | 17, 2011 | Cavaliers | | Timberwolves | |
| January | 18, 2011 | Cavaliers | | Kings | |
| January | 21, 2011 | Bucks | | Cavaliers | |
| January | 24, 2011 | Cavaliers | | Suns | |
| January | 25, 2011 | Wizards | | Cavaliers | |
| January | 27, 2011 | Knicks | | Cavaliers | |
| January | 29, 2011 | Cavaliers | | Wizards | |
| January | 30, 2011 | Jazz | | Cavaliers | |
| January | 31, 2011 | Pelicans | | Cavaliers | |
| February | 1, 2011 | Cavaliers | | Pistons | |
| February | 5, 2011 | Cavaliers | | Thunder | |
| February | 8, 2011 | Mavericks | | Cavaliers | |
| February | 14, 2011 | Celtics | | Cavaliers | |
| February | 15, 2011 | 76ers | | Cavaliers | |
| February | 16, 2011 | Cavaliers | | Pistons | |
| February | 19, 2011 | Thunder | | Cavaliers | |
| February | 22, 2011 | Cavaliers | | Bucks | |
| February | 24, 2011 | Hornets | | Cavaliers | |
| February | 25, 2011 | SuperSonics | | Cavaliers | |
| March | 1, 2011 | Cavaliers | | Hornets | |
| March | 4, 2011 | Magic | | Cavaliers | |
| March | 5, 2011 | Lakers | | Cavaliers | |
| March | 6, 2011 | Cavaliers | | 76ers | |
| March | 8, 2011 | Cavaliers | | Pelicans | |
| March | 9, 2011 | Timberwolves | | Cavaliers | |
| March | 10, 2011 | Cavaliers | | Raptors | |
| March | 12, 2011 | Suns | | Cavaliers | |
| March | 15, 2011 | Cavaliers | | Heat | |
| March | 16, 2011 | Cavaliers | | Pacers | |
| March | 21, 2011 | Cavaliers | | Suns | |
| March | 30, 2011 | Bulls | | Cavaliers | |
| April | 1, 2011 | Pistons | | Cavaliers | |
| April | 3, 2011 | Cavaliers | | Celtics | |
| April | 5, 2011 | Cavaliers | | Mavericks | |
| April | 9, 2011 | 76ers | | Cavaliers | |
| April | 10, 2011 | Raptors | | Cavaliers | |
| April | 15, 2011 | Cavaliers | | Bulls | |
| April | 18, 2011 | Cavaliers | | Magic | |
| April | 20, 2011 | Suns | | Cavaliers | |
| April | 22, 2011 | Cavaliers | | Jazz | |
| April | 28, 2011 | Bucks | | Cavaliers | |
| May | 1, 2011 | Cavaliers | | Wizards | |
| May | 3, 2011 | Grizzlies | | Cavaliers | |