| month | day | visitor | score | home | score |
|---|
| November | 3, 2009 | Heat | 99 | Grizzlies | 130 |
| November | 4, 2009 | Bucks | 123 | Grizzlies | 96 |
| November | 5, 2009 | Grizzlies | 100 | 76ers | 116 |
| November | 9, 2009 | Grizzlies | 93 | Celtics | 109 |
| November | 10, 2009 | Grizzlies | 104 | Bucks | 124 |
| November | 18, 2009 | Thunder | 92 | Grizzlies | 108 |
| November | 21, 2009 | Lakers | 75 | Grizzlies | 96 |
| November | 26, 2009 | Thunder | 93 | Grizzlies | 123 |
| November | 27, 2009 | Pelicans | 106 | Grizzlies | 119 |
| November | 28, 2009 | Grizzlies | 76 | Raptors | 93 |
| November | 29, 2009 | Grizzlies | 103 | Pacers | 120 |
| December | 1, 2009 | Grizzlies | 98 | Cavaliers | 104 |
| December | 5, 2009 | Grizzlies | 109 | Hornets | 110 |
| December | 10, 2009 | Celtics | 101 | Grizzlies | 92 |
| December | 11, 2009 | Nets | 98 | Grizzlies | 102 |
| December | 14, 2009 | Grizzlies | 89 | Blazers | 117 |
| December | 15, 2009 | Nuggets | 69 | Grizzlies | 105 |
| December | 16, 2009 | Kings | 108 | Grizzlies | 120 |
| December | 17, 2009 | Grizzlies | 100 | Suns | 104 |
| December | 21, 2009 | Grizzlies | 84 | Magic | 110 |
| December | 22, 2009 | Grizzlies | 91 | Celtics | 102 |
| December | 27, 2009 | Grizzlies | 101 | Kings | 114 |
| December | 29, 2009 | Hornets | 89 | Grizzlies | 101 |
| December | 30, 2009 | Jazz | 110 | Grizzlies | 83 |
| December | 31, 2009 | Pelicans | 113 | Grizzlies | 100 |
| January | 1, 2010 | Grizzlies | 105 | Magic | 114 |
| January | 2, 2010 | Grizzlies | 88 | Celtics | 97 |
| January | 3, 2010 | Suns | 113 | Grizzlies | 94 |
| January | 4, 2010 | Suns | 117 | Grizzlies | 104 |
| January | 5, 2010 | Wizards | 111 | Grizzlies | 117 |
| January | 9, 2010 | Pelicans | 97 | Grizzlies | 86 |
| January | 11, 2010 | Grizzlies | 113 | Thunder | 99 |
| January | 14, 2010 | Magic | 103 | Grizzlies | 106 |
| January | 15, 2010 | Cavaliers | 80 | Grizzlies | 97 |
| January | 16, 2010 | Pistons | 88 | Grizzlies | 125 |
| January | 18, 2010 | Grizzlies | 110 | Heat | 134 |
| January | 20, 2010 | Grizzlies | 90 | Suns | 103 |
| January | 21, 2010 | Celtics | 96 | Grizzlies | 83 |
| January | 22, 2010 | Pistons | 97 | Grizzlies | 115 |
| January | 31, 2010 | Heat | 100 | Grizzlies | 108 |
| February | 2, 2010 | Cavaliers | 80 | Grizzlies | 107 |
| February | 4, 2010 | Grizzlies | 98 | Lakers | 115 |
| February | 7, 2010 | Grizzlies | 100 | Cavaliers | 107 |
| February | 8, 2010 | Grizzlies | 110 | Timberwolves | 114 |
| February | 12, 2010 | Raptors | 88 | Grizzlies | 79 |
| February | 13, 2010 | Pistons | 101 | Grizzlies | 104 |
| February | 14, 2010 | Magic | 104 | Grizzlies | 81 |
| February | 15, 2010 | Wizards | 128 | Grizzlies | 111 |
| February | 18, 2010 | Grizzlies | 81 | Bucks | 88 |
| February | 20, 2010 | Mavericks | 76 | Grizzlies | 82 |
| February | 21, 2010 | Grizzlies | 50 | Nuggets | 92 |
| February | 26, 2010 | Timberwolves | 109 | Grizzlies | 85 |
| February | 27, 2010 | Grizzlies | 89 | Thunder | 98 |
| March | 2, 2010 | Grizzlies | 81 | Magic | 101 |
| March | 6, 2010 | Bulls | 84 | Grizzlies | 78 |
| March | 9, 2010 | Grizzlies | 90 | Bucks | 113 |
| March | 10, 2010 | Nuggets | 94 | Grizzlies | 82 |
| March | 15, 2010 | Grizzlies | 78 | Nuggets | 96 |
| March | 16, 2010 | Grizzlies | 105 | Heat | 127 |
| March | 17, 2010 | Grizzlies | 117 | SuperSonics | 122 |
| March | 19, 2010 | Bucks | 99 | Grizzlies | 84 |
| March | 20, 2010 | Pacers | 119 | Grizzlies | 92 |
| March | 22, 2010 | Heat | 118 | Grizzlies | 103 |
| March | 25, 2010 | Grizzlies | 85 | Mavericks | 92 |
| March | 27, 2010 | Grizzlies | 71 | Cavaliers | 86 |
| March | 29, 2010 | 76ers | 104 | Grizzlies | 86 |
| April | 1, 2010 | Grizzlies | 84 | Wizards | 110 |
| April | 3, 2010 | Grizzlies | 82 | Thunder | 92 |
| April | 4, 2010 | Grizzlies | 76 | 76ers | 107 |
| April | 6, 2010 | Wizards | 116 | Grizzlies | 102 |
| April | 7, 2010 | Grizzlies | 93 | Pelicans | 120 |
| April | 8, 2010 | Blazers | 104 | Grizzlies | 96 |
| April | 13, 2010 | Grizzlies | 86 | 76ers | 102 |
| April | 14, 2010 | SuperSonics | 122 | Grizzlies | 76 |
| April | 15, 2010 | Grizzlies | 62 | Suns | 110 |
| April | 16, 2010 | Grizzlies | 67 | Bulls | 89 |
| April | 18, 2010 | Nuggets | 112 | Grizzlies | 81 |
| April | 20, 2010 | Grizzlies | 87 | Nets | 80 |
| April | 26, 2010 | Knicks | 111 | Grizzlies | 103 |
| April | 28, 2010 | Grizzlies | 88 | Knicks | 94 |
| April | 29, 2010 | Grizzlies | 80 | Jazz | 102 |
| May | 2, 2010 | Grizzlies | 94 | Pistons | 91 |